Priory Events

14 Aug

Seminar with Leading US Addiction Specialist: Personalized Medicine Treatment for Alcohol Use Disorders

11:00 AM

Priory Lane


SW15 5JJ


Contact name: Nick Hazell

Contact email:

Contact telephone: 07827 850 341

Contact mobile: -

“Alcohol use Disorder is a heterogeneous condition, with symptomatic individuals varying in psychopathology, pathogenicity, treatment response, and prognosis. As a result, treatment response to standard medications can be unpredictable.  

Over 20 years of dedicated research has identified the serotonin-3 receptor system to be critical to the expression of the rewarding effects and abuse liability of alcohol.  Indeed, serotonin-3 receptors are one of the first to fire to express the rewarding effects of alcohol.  The effects of the serotonin-3 receptor are modulated not only by genetic differences at that receptor but also by molecular variants at the serotonin transporter, which gates about 60% of serotonin function.  We have discovered that the serotonin-3 receptor blocker, ondansetron, is efficacious treatment for alcohol use disorder among those with selective genetic variation at either or both the serotonin-3 receptor and the serotonin transporter.  This finding offers the possibility of pre-screening individuals with alcohol use disorder with these selective serotonergic genotypes, and subsequently, administering them very low dose ondansetron as a treatment agent.  Our work opens up the new horizon of personalized medicine treatment for alcohol use disorder”

Learning points:

1. Understand the role of the serotonin system in alcohol use disorder

2. Understand the importance of genetic variations within the serotonin system as predictors of treatment response to ondansetron

3. Update clinicians on new endpoints for characterizing alcohol use disorder and response to treatment 

Profile link:

Professor Bankole Johnson DSc., M.D., MB.ChB., MPhil, FRCPsych, DFAPA, FACFEI

Chairman Department of Psychiatry
Professor Department of Psychiatry
Professor of Anatomy and Neurobiology
Professor of Pharmacology
University of Maryland School of Medicine
Baltimore, Maryland, USA

This seminar is for GPs and Health Professionals only, it is free and attendees will get a Certificate of Attendance for CPD purposes.  If you wish to attend please contact Nick Hazell on 07827 850 341 or email